DENND2A

Across TCGA patient cohorts, DENND2A mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2A-associated genes across cancer lineages are C-Raf, N-Ras, and Cyclin-B1. Each is linked with DENND2A in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND2A-to-partner and partner-to-DENND2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by DENND2A-low versus DENND2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2A→partner) and Y-score (partner→DENND2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.171	+1.784	<.001	<.001	3	3
BLCA	N-Ras →	+0.140	+3.025	.013	.018	3	3
UCEC	Cyclin-B1 →	+0.670	+2.000	<.001	<.001	3	3
LUAD	Heregulin →	-0.139	-3.000	.024	.035	3	2
LUAD	MYH11 →	-1.183	-3.169	.002	.018	3	2
LUAD	Bak →	+0.140	+2.618	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

C-Raf by DENND2A expression — UCEC

Explore this box plot interactively →