DENND2A

Across TCGA cell cohorts, DENND2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,006 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DENND2A-associated GO terms across cancer lineages are Positive regulation of supramolecular fiber organization, Protein depolymerization, and Positive regulation of cytoskeleton organization. Each is linked with DENND2A in more than 11 cancer types. Because this analysis shows association rather than direction, both DENND2A-to-partner and partner-to-DENND2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of supramolecular fiber organization grouped by DENND2A-low versus DENND2A-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2A→partner) and Y-score (partner→DENND2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of supramolecular fiber organization →	+0.082	+1.158	<.001	<.001	3	12
LIVER	Protein depolymerization →	+0.104	+2.577	.002	.002	3	11
BREAST	Positive regulation of cytoskeleton organization →	+0.066	+1.010	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of cilium assembly →	+0.089	+1.966	<.001	<.001	3	10
LUNG_SCLC	Regulation of mitotic nuclear division →	+0.091	+1.941	<.001	<.001	3	10
BREAST	Positive regulation of cell-substrate junction organization →	+0.121	+1.226	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,006 associations by consensus.

Positive regulation of supramolecular fiber organization by DENND2A expression — BREAST

Explore this box plot interactively →