DENND2A

Across TCGA cell cohorts, DENND2A mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DENND2A-associated genes across cancer lineages are LY6G6F, ZNF804B, and VENTX. Each is linked with DENND2A in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND2A-to-partner and partner-to-DENND2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by DENND2A-low versus DENND2A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2A→partner) and Y-score (partner→DENND2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LY6G6F →	+0.040	+5.087	<.001	.004	3	2
BLOOD_Lymphoma	ZNF804B →	+0.010	+2.765	<.001	.007	3	2
KIDNEY	VENTX →	+0.014	+4.121	<.001	.006	3	1
KIDNEY	SVOP →	+0.034	+4.121	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	FHL5 →	+0.033	+3.510	.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	RFPL3 →	+0.067	+3.632	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

LY6G6F by DENND2A expression — URINARY_TRACT

Explore this box plot interactively →