Across TCGA pan-cancer cohorts, DENND1C Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DENND1C data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DENND1C Mutation is associated with better overall survival. In most high-consensus cancer types, elevated DENND1C expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, KICH, and STAD are the cancer types where DENND1C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.660	.022	14	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
STAD	OS	Median	IV	0.074	0.496	.002	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
LIHC	DFS	Median	II,III,IV	0.065	0.431	<.001	6	view →
SKCM	DFS	Median	All	0.843	0.714	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: DENND1C tumor-vs-normal RNA expression · all DENND1C data types