Across TCGA pan-cancer cohorts, DENND1C mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DENND1C data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DENND1C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DENND1C expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where DENND1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.840	0.452	<.001	39	view →
HNSC	DFS	Median	All	0.685	0.826	.022	9	view →
PDAC	DFS	Median	All	0.378	0.201	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DENND1C tumor-vs-normal RNA expression · all DENND1C data types