Across TCGA pan-cancer cohorts, DENND1B Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated DENND1B data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DENND1B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DENND1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.
HNSC, BLCA, and LUSC are the cancer types where DENND1B Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.