Across TCGA pan-cancer cohorts, DENND1B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DENND1B data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DENND1B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DENND1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where DENND1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.857	.023	32	view →
LSCC	DFS	Tertile	II,III,IV	0.400	0.856	.001	22	view →
CCRCC	DFS	Median	All	1.000	0.811	.006	21	view →
HNSC	OS	Tertile	III,IV	0.527	0.850	.020	5	view →
PDAC	DFS	Quartile	III,IV	0.957	0.339	.024	3	view →
GBM	DFS	Median	All	0.854	0.692	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: DENND1B tumor-vs-normal RNA expression · all DENND1B data types