Across TCGA patient cohorts, DENND1B RNA expression is significantly associated with the protein abundance of many other proteins, with 13,195 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DENND1B-associated proteins across cancer lineages are RNPEP, DGKA, and NUCKS1_S214. Each is linked with DENND1B in more than 6 cancer types. Because this analysis shows association rather than direction, both DENND1B-to-partner and partner-to-DENND1B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1B→partner) and Y-score (partner→DENND1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNPEP →	+0.318	+0.946	.008	.001	3	7
OV	DGKA →	+0.350	+0.464	.001	<.001	3	4
BRCA	NUCKS1_S214 →	+0.453	+0.707	.006	.007	3	4
PDAC	ZBTB38_S130 →	-0.574	-0.442	<.001	<.001	3	4
PDAC	COG3 →	+0.237	+0.370	<.001	<.001	3	4
BRCA	DENND1B_S596 →	+0.945	+1.303	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,195 associations by consensus.

Exploration

DENND1B survival (RNA) · tumor vs normal (RNA) · all DENND1B data types