Across TCGA patient cohorts, DENND1B protein abundance is significantly associated with the RNA expression of many other genes, with 5,004 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND1B-associated genes across cancer lineages are ANKRD44-IT1, ANKRD44, and FGD2. Each is linked with DENND1B in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND1B-to-partner and partner-to-DENND1B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1B→partner) and Y-score (partner→DENND1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ANKRD44-IT1 →	+0.680	+0.252	<.001	<.001	3	3
LUAD	ANKRD44 →	+0.580	+0.218	<.001	.002	3	3
LSCC	FGD2 →	+0.631	+0.206	<.001	<.001	3	3
LSCC	SMIM13 →	-0.435	-0.193	<.001	<.001	3	3
LSCC	TUBB2B →	-1.354	-0.191	<.001	<.001	3	3
LUAD	STS →	+0.481	+0.152	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,004 associations by consensus.

Exploration

DENND1B survival (RNA) · tumor vs normal (RNA) · all DENND1B data types