Across TCGA patient cohorts, DENND1B mutation is significantly associated with the RNA expression of many other genes, with 4,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND1B-associated genes across cancer lineages are ATP6V1G1P3, RER1, and C18orf54. Each is linked with DENND1B in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND1B-to-partner and partner-to-DENND1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1B→partner) and Y-score (partner→DENND1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATP6V1G1P3 →	+0.305	+2.767	<.001	.009	3	3
UCEC	RER1 →	+0.253	+2.694	.001	<.001	3	3
UCEC	C18orf54 →	+0.497	+1.947	.001	<.001	3	3
UCEC	MRTO4 →	+0.413	+4.180	<.001	<.001	3	3
SKCM	ENO1 →	+0.582	+3.331	.003	.005	3	3
SKCM	RNA5SP286 →	+0.077	+3.784	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,328 associations by consensus.

Exploration

DENND1B survival (RNA) · tumor vs normal (RNA) · all DENND1B data types