Across TCGA patient cohorts, DENND1B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND1B-associated genes across cancer lineages are FASN, GAPDH, and JNK2. Each is linked with DENND1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND1B-to-partner and partner-to-DENND1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1B→partner) and Y-score (partner→DENND1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.379	+2.321	.006	.005	3	2
UCEC	GAPDH →	+0.376	+2.459	.047	.018	3	2
UCEC	JNK2 →	+0.243	+2.392	<.001	<.001	3	2
UCEC	MEK1 →	+0.538	+2.874	<.001	<.001	3	2
UCEC	Notch1 →	+0.147	+2.013	.003	.016	3	2
UCEC	PDCD4 →	-0.449	-2.222	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

DENND1B survival (RNA) · tumor vs normal (RNA) · all DENND1B data types