Across TCGA cell cohorts, DENND1B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DENND1B-associated genes across cancer lineages are KRTAP6-1, KRTAP21-1, and OR4F4. Each is linked with DENND1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND1B-to-partner and partner-to-DENND1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1B→partner) and Y-score (partner→DENND1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP6-1 →	+0.075	+5.022	<.001	.002	3	1
SKIN	KRTAP21-1 →	+0.037	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR4F4 →	+0.014	+3.688	.001	.002	3	1
LARGE_INTESTINE	CCR8 →	+0.154	+3.554	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

DENND1B survival (RNA) · tumor vs normal (RNA) · all DENND1B data types