DELE1

Across TCGA patient cohorts, DELE1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DELE1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ERK2. Each is linked with DELE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DELE1-to-partner and partner-to-DELE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DELE1-low versus DELE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DELE1→partner) and Y-score (partner→DELE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.558	+1.604	.019	.041	3	2
UCEC	EGFR_pY1068 →	-0.269	-1.906	.007	.016	3	1
UCEC	ERK2 →	+0.186	+2.321	.016	.033	3	1
UCEC	FASN →	+0.409	+1.906	.009	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.161	-1.893	.017	.016	3	1
UCEC	MEK1 →	+0.349	+2.459	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by DELE1 expression — UCEC

Explore this box plot interactively →