DELE1

Across TCGA cell cohorts, DELE1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DELE1-associated genes across cancer lineages are OR52E8, TMEM114, and MCHR2. Each is linked with DELE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DELE1-to-partner and partner-to-DELE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E8 grouped by DELE1-low versus DELE1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DELE1→partner) and Y-score (partner→DELE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR52E8 →	+0.032	+5.415	<.001	.004	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1
CNS	MCHR2 →	+0.083	+3.930	<.001	.005	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
BLOOD_Leukemia	HRG →	+0.338	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR52E8 by DELE1 expression — SKIN

Explore this box plot interactively →