DEK

Across TCGA pan-cancer cohorts, DEK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DEK data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DEK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DEK expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where DEK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	39	view →
LSCC	OS	Quartile	All	1.000	0.784	.010	29	view →
PDAC	DFS	Tertile	III,IV	0.349	0.845	.001	17	view →
CCRCC	DFS	Median	III,IV	0.719	0.432	.010	11	view →
LUAD	OS	Quartile	All	0.968	0.723	.006	7	view →
UCEC	OS	Median	All	0.910	0.985	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DEK–HNSC (OS)

Open the HNSC breakdown →