DEK

Across TCGA patient cohorts, DEK mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEK-associated genes across cancer lineages are Notch1, P-Cadherin, and eEF2. Each is linked with DEK in more than 1 cancer types. Because this analysis shows association rather than direction, both DEK-to-partner and partner-to-DEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DEK-low versus DEK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEK→partner) and Y-score (partner→DEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.226	+3.594	<.001	.001	3	2
UCEC	P-Cadherin →	-0.132	-1.990	.026	.030	3	2
UCEC	eEF2 →	+0.483	+3.321	.001	.009	3	1
UCEC	INPP4B →	-0.361	-2.584	.006	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-2.584	.003	.010	3	1
UCEC	JNK2 →	+0.207	+1.807	.011	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Notch1 by DEK expression — UCEC

Explore this box plot interactively →