DEK

Across TCGA cell cohorts, DEK mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEK-associated genes across cancer lineages are MSGN1, SLN, and TAFA1. Each is linked with DEK in more than 1 cancer types. Because this analysis shows association rather than direction, both DEK-to-partner and partner-to-DEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by DEK-low versus DEK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEK→partner) and Y-score (partner→DEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.080	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	SLN →	+0.143	+3.334	.004	.008	3	1
LARGE_INTESTINE	TAFA1 →	+0.239	+3.103	.001	.004	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.522	+3.520	.003	.005	3	1
LARGE_INTESTINE	DAZ4 →	+0.141	+3.562	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MSGN1 by DEK expression — LARGE_INTESTINE

Explore this box plot interactively →