DEGS2

Across TCGA pan-cancer cohorts, DEGS2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DEGS2 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DEGS2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DEGS2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC and PDAC are the cancer types where DEGS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.350	.002	23	view →
PDAC	OS	Median	All	0.820	0.319	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

DEGS2–LSCC (DFS)

Open the LSCC breakdown →