DEGS2

Across TCGA patient cohorts, DEGS2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,822 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DEGS2-associated genes across cancer lineages are COMP, MLPH, and ZMAT3. Each is linked with DEGS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEGS2-to-partner and partner-to-DEGS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEGS2 versus COMP in CCRCC, with a Pearson correlation of -0.96.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEGS2→partner) and Y-score (partner→DEGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COMP →	-2.349	-1.246	<.001	<.001	3	3
BRCA	MLPH →	+1.788	+0.774	.003	.001	3	3
CCRCC	ZMAT3 →	-1.226	-1.146	<.001	.003	3	2
LSCC	HECW1 →	-0.849	-1.228	.002	.002	3	2
BRCA	ITPK1 →	+0.765	+0.895	<.001	<.001	3	2
OV	ICAM2 →	-1.062	-1.096	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,822 associations by consensus.

DEGS2 vs COMP — CCRCC

Explore this scatter interactively →