DEGS2

Across TCGA patient cohorts, DEGS2 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DEGS2-associated genes across cancer lineages are Melanocytes, CD8+ Tem, and NK cells. Each is linked with DEGS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEGS2-to-partner and partner-to-DEGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanocytes grouped by DEGS2-low versus DEGS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEGS2→partner) and Y-score (partner→DEGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Melanocytes →	+0.015	+2.901	.013	.032	3	1
STAD	CD8+ Tem →	+0.008	+3.982	.009	.014	3	1
STAD	NK cells →	+0.006	+5.012	<.001	.003	3	1
CESC	Macrophages →	+0.037	+3.216	.003	.046	3	1
UCEC	lymphatic Endothelial cells →	-0.023	-3.129	.045	.019	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Melanocytes by DEGS2 expression — COAD

Explore this box plot interactively →