DEGS2

Across TCGA cell cohorts, DEGS2 mutation is significantly associated with the mutation status of many other genes, with 2,007 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEGS2-associated genes across cancer lineages are SYNC, ENO4, and TTC16. Each is linked with DEGS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEGS2-to-partner and partner-to-DEGS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNC grouped by DEGS2-low versus DEGS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEGS2→partner) and Y-score (partner→DEGS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYNC →	+5.050	+4.000	.008	.008	1	3
LARGE_INTESTINE	ENO4 →	+2.865	+4.217	.007	.007	1	3
BLOOD_Leukemia	TTC16 →	+3.465	+3.913	<.001	<.001	1	3
BLOOD_Leukemia	ANKRD10 →	+5.050	+4.000	.008	.008	1	2
BLOOD_Leukemia	MARVELD2 →	+3.465	+3.913	<.001	<.001	1	2
BLOOD_Leukemia	ANAPC1 →	+3.313	+3.430	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,007 associations by consensus.

SYNC by DEGS2 expression — BLOOD_Leukemia

Explore this box plot interactively →