DEGS1

Across TCGA pan-cancer cohorts, DEGS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DEGS1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DEGS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DEGS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where DEGS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.816	0.469	<.001	110	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	23	view →
UCEC	DFS	Quartile	III,IV	1.000	0.344	.027	12	view →
PDAC	OS	Quartile	All	0.372	0.603	.004	12	view →
LSCC	DFS	Quartile	All	0.519	0.852	.025	5	view →
GBM	OS	Median	All	0.279	0.474	.007	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DEGS1–HNSC (DFS)

Open the HNSC breakdown →