Across TCGA pan-cancer cohorts, DEFB136 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated DEFB136 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher DEFB136 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFB136 expression acts as an unfavorable survival marker.

ESCA are the cancer types where DEFB136 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: DEFB136 tumor-vs-normal RNA expression · all DEFB136 data types