Across TCGA cell cohorts, DEFB136 RNA expression is significantly associated with the mutation status of many other genes, with 40 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DEFB136-associated genes across cancer lineages are UHRF1BP1L, PCDHB2, and ADAMTS18. Each is linked with DEFB136 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB136-to-partner and partner-to-DEFB136 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB136→partner) and Y-score (partner→DEFB136) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UHRF1BP1L →	+4.772	+0.275	.002	<.001	3	1
CNS	PCDHB2 →	+4.357	+0.229	.004	<.001	3	1
CNS	ADAMTS18 →	+4.035	+0.197	.006	<.001	3	1
LUNG_NSCLC_LUAD	PIEZO1 →	+3.681	+0.086	.009	<.001	3	1
LUNG_NSCLC_LUAD	LIG1 →	+3.681	+0.086	.009	<.001	3	1
LUNG_NSCLC_LUAD	POU6F2 →	+3.681	+0.086	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

DEFB136 survival (RNA) · tumor vs normal (RNA) · all DEFB136 data types