Across TCGA patient cohorts, DEFB132 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB132-associated genes across cancer lineages are MIR3914-1, OR10G9, and OFD1P11Y. Each is linked with DEFB132 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB132-to-partner and partner-to-DEFB132 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB132→partner) and Y-score (partner→DEFB132) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3914-1 →	+0.565	+8.066	<.001	.007	3	1
SKCM	OR10G9 →	+0.039	+7.816	<.001	.008	3	1
SKCM	OFD1P11Y →	+0.039	+7.816	<.001	.008	3	1
UCEC	TSPY8 →	+0.039	+8.066	<.001	.007	3	1
SKCM	RN7SKP157 →	+0.124	+7.816	<.001	.008	3	1
SKCM	MIR3152 →	+0.478	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

DEFB132 survival (RNA) · tumor vs normal (RNA) · all DEFB132 data types