DEFB131E

Across TCGA pan-cancer cohorts, DEFB131E RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DEFB131E’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DEFB131E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFB131E is over-expressed in tumor, although a few such as PRAD and READ show the opposite, repressed pattern.

KIRC, LUAD, and THCA are the cancer types where DEFB131E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB131E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.643	<.001	12	view →
LUAD	All	II,III,IV	+0.217	<.001	8	view →
THCA	Female	III,IV	+1.124	<.001	7	view →
KICH	Female	II,III,IV	+0.191	<.001	7	view →
BRCA	All	III,IV	+0.332	<.001	6	view →
HNSC	All	II,III,IV	+0.063	.014	6	view →
LIHC	All	All	+0.062	<.001	6	view →
LUSC	All	All	+0.182	<.001	5	view →
CHOL	All	All	+0.266	<.001	3	view →
PRAD	All	All	−0.877	<.001	2	view →
ESCA	All	II,III,IV	+0.295	.007	2	view →
READ	All	All	−0.283	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DEFB131E–KIRC

Open the KIRC breakdown →