DEFB130C

Across TCGA pan-cancer cohorts, DEFB130C RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated DEFB130C data layer.

The strongest signal is observed in mesothelioma (MESO), where higher DEFB130C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB130C expression acts as an unfavorable survival marker, although some lineages such as KIRC and PRAD show a favorable association.

MESO, LUSC, and SKCM are the cancer types where DEFB130C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.084	0.560	<.001	45	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
SKCM	DFS	Tertile	II,III,IV	0.412	0.719	.004	27	view →
ACC	OS	Tertile	All	0.224	0.658	.007	27	view →
PCPG	DFS	Tertile	All	0.631	0.897	<.001	27	view →
GBM	DFS	Tertile	All	0.143	0.257	.044	18	view →
READ	DFS	Tertile	III,IV	0.419	0.766	.013	18	view →
UCEC	OS	Tertile	IV	0.197	0.513	.045	18	view →
KIRC	DFS	Tertile	II,III,IV	0.889	0.699	.023	17	view →
COAD	OS	Tertile	All	0.349	0.615	.021	15	view →
LUAD	OS	Tertile	II,III,IV	0.110	0.257	.042	12	view →
PAAD	OS	Tertile	II,III,IV	0.369	0.575	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

DEFB130C–MESO (OS)

Open the MESO breakdown →