DEFB130A

Across TCGA patient cohorts, DEFB130A RNA expression is significantly associated with the mutation status of many other genes, with 12 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DEFB130A-associated genes across cancer lineages are LYRM1, ETV3, and TICAM1. Each is linked with DEFB130A in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB130A-to-partner and partner-to-DEFB130A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYRM1 grouped by DEFB130A-low versus DEFB130A-high in HNSC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB130A→partner) and Y-score (partner→DEFB130A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LYRM1 →	+7.954	+0.124	.008	<.001	3	1
HNSC	ETV3 →	+7.954	+0.124	.008	<.001	3	1
HNSC	TICAM1 →	+7.954	+0.124	.008	<.001	3	1
HNSC	DUT →	+7.954	+0.124	.008	<.001	3	1
HNSC	PSRC1 →	+7.954	+0.129	.008	<.001	3	1
HNSC	CRABP2 →	+7.954	+0.124	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LYRM1 by DEFB130A expression — HNSC

Explore this box plot interactively →