DEFB123

Across TCGA patient cohorts, DEFB123 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB123-associated genes across cancer lineages are TUBB8P9, CCDC58P2, and STRIT1. Each is linked with DEFB123 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB123-to-partner and partner-to-DEFB123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB8P9 grouped by DEFB123-low versus DEFB123-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB123→partner) and Y-score (partner→DEFB123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TUBB8P9 →	+0.035	+4.296	.008	.008	3	1
SKCM	CCDC58P2 →	+0.094	+4.970	<.001	.005	3	1
SKCM	STRIT1 →	+0.150	+4.296	<.001	.008	3	1
SKCM	RN7SL446P →	+0.163	+4.513	<.001	.009	3	1
LUAD	RNA5SP177 →	+0.322	+7.930	<.001	.008	3	1
LUAD	LINC00387 →	+0.089	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

TUBB8P9 by DEFB123 expression — SKCM

Explore this box plot interactively →