DEFB123

Across TCGA cell cohorts, DEFB123 RNA expression is significantly associated with the mutation status of many other genes, with 106 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible DEFB123-associated genes across cancer lineages are KMT2A, GGA1, and DICER1. Each is linked with DEFB123 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB123-to-partner and partner-to-DEFB123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT2A grouped by DEFB123-low versus DEFB123-high in LUNG_SCLC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB123→partner) and Y-score (partner→DEFB123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KMT2A →	+4.058	+0.062	.007	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	GGA1 →	+4.357	+0.085	.006	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	DICER1 →	+4.357	+0.085	.006	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	JAG1 →	+4.357	+0.085	.006	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	IQCH →	+5.357	+0.113	.003	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	TJP1 →	+4.357	+0.085	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

KMT2A by DEFB123 expression — LUNG_SCLC

Explore this box plot interactively →