Across TCGA pan-cancer cohorts, DEFB121 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DEFB121 data layer compared with 10 for mass-spec protein.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher DEFB121 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB121 expression acts as an unfavorable survival marker.
COAD, HNSC, and BLCA are the cancer types where DEFB121 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.