Across TCGA pan-cancer cohorts, DEFB115 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated DEFB115 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DEFB115 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB115 expression acts as an unfavorable survival marker.

LUAD are the cancer types where DEFB115 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: DEFB115 tumor-vs-normal RNA expression · all DEFB115 data types