DEFB114

Across TCGA patient cohorts, DEFB114 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible DEFB114-associated genes across cancer lineages are ERHP2, RN7SL591P, and RN7SL332P. Each is linked with DEFB114 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB114-to-partner and partner-to-DEFB114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERHP2 grouped by DEFB114-low versus DEFB114-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB114→partner) and Y-score (partner→DEFB114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERHP2 →	+0.181	+4.352	<.001	.008	3	2
UCEC	RN7SL591P →	+0.190	+5.464	<.001	.001	3	2
UCEC	RN7SL332P →	+0.308	+4.868	<.001	.004	3	2
LUSC	EIF4A3P1 →	+0.118	+5.978	.007	.002	3	2
HNSC	SEPTIN14P19 →	+0.059	+5.822	<.001	.003	3	1
UCEC	RPS28P1 →	+0.293	+4.442	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ERHP2 by DEFB114 expression — UCEC

Explore this box plot interactively →