Across TCGA patient cohorts, DEFB113 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible DEFB113-associated genes across cancer lineages are HSPD1P13, TRGJP, and RNA5SP325. Each is linked with DEFB113 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB113-to-partner and partner-to-DEFB113 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB113→partner) and Y-score (partner→DEFB113) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	HSPD1P13 →	+0.031	+5.758	<.001	.003	3	2
BRCA	TRGJP →	+0.898	+5.610	<.001	.004	3	2
UCEC	RNA5SP325 →	+1.930	+3.296	<.001	.008	3	2
UCEC	RNA5SP279 →	+0.777	+4.582	<.001	.005	3	2
LIHC	BUB1P1 →	+0.074	+5.447	<.001	.005	3	1
BRCA	SLC2A13P1 →	+0.157	+5.096	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Exploration

DEFB113 survival (RNA) · tumor vs normal (RNA) · all DEFB113 data types