DEFB112

Across TCGA patient cohorts, DEFB112 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,890 significant associations in total. LGG shows the largest number of these associations.

The most reproducible DEFB112-associated GO terms across cancer lineages are Neuron projection organization, Regulation of postsynaptic membrane neurotransmitter receptor levels, and tRNA 5'-end processing. Each is linked with DEFB112 in more than 3 cancer types. Because this analysis shows association rather than direction, both DEFB112-to-partner and partner-to-DEFB112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuron projection organization grouped by DEFB112-low versus DEFB112-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB112→partner) and Y-score (partner→DEFB112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Neuron projection organization →	+0.136	+0.052	<.001	.006	2	4
STAD	Regulation of postsynaptic membrane neurotransmitter receptor levels →	+0.097	+0.072	<.001	.001	3	3
STAD	tRNA 5'-end processing →	+0.137	+0.028	<.001	.009	3	3
BRCA	Regulation of postsynaptic neurotransmitter receptor internalization →	+0.110	+0.016	<.001	<.001	3	3
STAD	Postsynapse organization →	+0.078	+0.064	<.001	.003	3	3
STAD	Synaptic vesicle cytoskeletal transport →	+0.108	+0.031	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,890 associations by consensus.

Neuron projection organization by DEFB112 expression — ESCA

Explore this box plot interactively →