DEFB112

Across TCGA patient cohorts, DEFB112 protein abundance is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DEFB112-associated genes across cancer lineages are PXMP4, COMP, and SFRP4. Each is linked with DEFB112 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB112-to-partner and partner-to-DEFB112 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEFB112 versus PXMP4 in LSCC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB112→partner) and Y-score (partner→DEFB112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PXMP4 →	-0.639	-1.952	.001	.001	3	1
LSCC	COMP →	+1.614	+1.678	<.001	.001	3	1
LSCC	SFRP4 →	+1.010	+1.398	.001	.007	3	1
LSCC	AGXT2 →	+0.028	+1.237	.003	.002	3	1
LSCC	TNFSF4 →	+0.382	+1.125	.008	.005	3	1
LSCC	HCRTR1 →	-0.530	-1.741	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

DEFB112 vs PXMP4 — LSCC

Explore this scatter interactively →