DEFB112

Across TCGA patient cohorts, DEFB112 mutation is significantly associated with the RNA expression of many other genes, with 461 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB112-associated genes across cancer lineages are SMSP1, RNU6-189P, and UTP18. Each is linked with DEFB112 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB112-to-partner and partner-to-DEFB112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMSP1 grouped by DEFB112-low versus DEFB112-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB112→partner) and Y-score (partner→DEFB112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMSP1 →	+0.035	+3.330	<.001	.008	3	2
LUAD	RNU6-189P →	+0.286	+3.473	<.001	.006	3	2
LUSC	UTP18 →	+0.450	+3.229	.008	.009	3	2
SKCM	KHDRBS1 →	+0.505	+3.616	.006	.001	3	2
LUSC	ABHD17AP8 →	+0.103	+2.900	.006	.005	3	2
LUSC	LONRF2P1 →	+0.047	+3.347	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 461 associations by consensus.

SMSP1 by DEFB112 expression — LUAD

Explore this box plot interactively →