DEFB112

Across TCGA patient cohorts, DEFB112 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DEFB112-associated genes across cancer lineages are Skeletal muscle, Fibroblasts, and Melanocytes. Each is linked with DEFB112 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB112-to-partner and partner-to-DEFB112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Skeletal muscle grouped by DEFB112-low versus DEFB112-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB112→partner) and Y-score (partner→DEFB112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Skeletal muscle →	+0.037	+2.881	.039	.031	3	1
HNSC	Fibroblasts →	+0.054	+5.339	<.001	.047	3	1
LUSC	Melanocytes →	-0.009	-3.051	.047	.021	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Skeletal muscle by DEFB112 expression — SKCM

Explore this box plot interactively →