Across TCGA pan-cancer cohorts, DEFB109B RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of DEFB109B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DEFB109B RNA is repressed in tumor relative to normal tissue. In most cancer types DEFB109B is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC are the cancer types where DEFB109B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB109B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.013	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: DEFB109B RNA expression & survival · all DEFB109B data types