DEFB1

Across TCGA pan-cancer cohorts, DEFB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DEFB1 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DEFB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where DEFB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.356	0.888	.001	39	view →
UCEC	OS	Median	All	1.000	0.864	.012	16	view →
HNSC	OS	Median	All	0.913	0.762	.011	8	view →
LSCC	DFS	Quartile	All	0.544	1.000	.040	2	view →
LUAD	OS	Tertile	III,IV	0.406	0.931	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DEFB1–PDAC (DFS)

Open the PDAC breakdown →