DEFB1

Across TCGA patient cohorts, DEFB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,779 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DEFB1-associated proteins across cancer lineages are EVPL, EPB41L1, and RAB3D. Each is linked with DEFB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DEFB1-to-partner and partner-to-DEFB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEFB1 versus EVPL in HNSC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB1→partner) and Y-score (partner→DEFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EVPL →	+0.692	+2.038	<.001	<.001	3	6
OV	EPB41L1 →	+0.603	+2.144	.001	.001	3	6
OV	RAB3D →	+0.810	+2.797	<.001	<.001	3	5
LUAD	CLMN →	+0.432	+1.993	.002	<.001	3	5
LSCC	ARF6 →	+0.298	+2.220	<.001	<.001	3	5
PDAC	TRIM29 →	+1.038	+1.873	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,779 associations by consensus.

DEFB1 vs EVPL — HNSC

Explore this scatter interactively →