DEFB1

Across TCGA patient cohorts, DEFB1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB1-associated genes across cancer lineages are RN7SKP132, RNA5SP420, and RNA5SP414. Each is linked with DEFB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB1-to-partner and partner-to-DEFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP132 grouped by DEFB1-low versus DEFB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB1→partner) and Y-score (partner→DEFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP132 →	+0.270	+5.877	<.001	.001	3	2
UCEC	RNA5SP420 →	+1.980	+4.552	<.001	.005	3	2
UCEC	RNA5SP414 →	+1.724	+4.840	<.001	.003	3	1
UCEC	RNA5SP412 →	+1.749	+4.552	<.001	.005	3	1
SKCM	MIR6752 →	+0.242	+4.199	<.001	.009	3	1
SKCM	LINC02351 →	+0.618	+4.313	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

RN7SKP132 by DEFB1 expression — UCEC

Explore this box plot interactively →