DEFA4

Across TCGA patient cohorts, DEFA4 RNA expression is significantly associated with the RNA expression of many other genes, with 6,371 significant associations in total. THYM shows the largest number of these associations.

The most reproducible DEFA4-associated genes across cancer lineages are DEFA3, CEACAM3, and VNN2. Each is linked with DEFA4 in more than 20 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEFA4 versus DEFA3 in LAML, with a Pearson correlation of 0.75.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	DEFA3 →	+2.225	+2.388	<.001	<.001	3	21
LAML	CEACAM3 →	+1.057	+2.150	<.001	<.001	3	20
THYM	VNN2 →	+1.121	+1.745	<.001	<.001	3	18
LAML	JAML →	+1.165	+1.491	<.001	<.001	3	18
PAAD	MIR223HG →	+0.961	+0.222	<.001	<.001	3	17
SKCM	CFP →	+1.010	+0.088	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,371 associations by consensus.

DEFA4 vs DEFA3 — LAML

Explore this scatter interactively →