DEFA4

Across TCGA patient cohorts, DEFA4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,827 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DEFA4-associated genes across cancer lineages are ADGRG3, AQP9, and CSF3R. Each is linked with DEFA4 in more than 8 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEFA4 versus ADGRG3 in PDAC, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADGRG3 →	+1.086	+1.384	<.001	<.001	3	9
BRCA	AQP9 →	+1.340	+1.013	<.001	<.001	3	8
COAD	CSF3R →	+1.295	+1.107	<.001	<.001	3	8
GBM	TREM1 →	+1.160	+0.462	<.001	<.001	3	8
PDAC	FCGR3B →	+1.734	+1.354	<.001	<.001	3	8
GBM	CXCR1 →	+1.427	+0.822	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,827 associations by consensus.

DEFA4 vs ADGRG3 — PDAC

Explore this scatter interactively →