DEFA4

Across TCGA patient cohorts, DEFA4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFA4-associated genes across cancer lineages are PEA-15, Src, and Bad_pS112. Each is linked with DEFA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15 grouped by DEFA4-low versus DEFA4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PEA-15 →	+0.146	+2.584	.047	.011	3	2
SKCM	Src →	-0.210	-2.584	.049	.011	3	1
SKCM	Bad_pS112 →	+0.193	+2.182	.024	.033	3	1
SKCM	Caveolin-1 →	-0.615	-2.321	.032	.033	3	1
SKCM	DJ-1 →	+0.250	+2.602	.002	.006	3	1
SKCM	Ku80 →	+0.276	+2.584	.030	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PEA-15 by DEFA4 expression — SKCM

Explore this box plot interactively →