DEFA4

Across TCGA cell cohorts, DEFA4 RNA expression is significantly associated with the RNA expression of many other genes, with 2,107 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEFA4-associated genes across cancer lineages are DEFA1, FAM71B, and C1QA. Each is linked with DEFA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEFA4 versus DEFA1 in BLOOD_Leukemia, with a Pearson correlation of 0.72.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFA1 →	+2.828	+1.030	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	FAM71B →	+0.023	+0.097	<.001	<.001	3	3
BLOOD_Lymphoma	C1QA →	+0.151	+0.067	<.001	<.001	3	3
BLOOD_Leukemia	DEFA3 →	+1.964	+2.508	<.001	<.001	3	3
BLOOD_Lymphoma	CRP →	+0.203	+0.095	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	GOT1L1 →	+0.022	+0.064	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,107 associations by consensus.

DEFA4 vs DEFA1 — BLOOD_Leukemia

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