DEFA4

Across TCGA cell cohorts, DEFA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 718 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEFA4-associated GO terms across cancer lineages are Exosomal secretion, Natural killer cell mediated immunity, and Natural killer cell mediated cytotoxicity. Each is linked with DEFA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Exosomal secretion grouped by DEFA4-low versus DEFA4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Exosomal secretion →	+0.116	+0.871	<.001	<.001	3	2
BLOOD_Leukemia	Natural killer cell mediated immunity →	+0.124	+0.870	<.001	<.001	3	2
BLOOD_Leukemia	Natural killer cell mediated cytotoxicity →	+0.106	+0.870	<.001	<.001	3	2
BLOOD_Leukemia	Response to zinc ion →	+0.101	+0.829	<.001	.004	3	1
BLOOD_Leukemia	Specification of animal organ identity →	-0.944	-0.908	<.001	.005	3	1
BLOOD_Leukemia	Response to lithium ion →	+0.108	+0.899	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 718 associations by consensus.

Exosomal secretion by DEFA4 expression — BLOOD_Leukemia

Explore this box plot interactively →