DEFA4

Across TCGA cell cohorts, DEFA4 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DEFA4-associated genes across cancer lineages are HTR3D. Each is linked with DEFA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR3D grouped by DEFA4-low versus DEFA4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HTR3D →	+0.020	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

HTR3D by DEFA4 expression — SKIN

Explore this box plot interactively →