DEF8

Across TCGA pan-cancer cohorts, DEF8 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DEF8 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DEF8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DEF8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC and GBM are the cancer types where DEF8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	1.000	0.826	.029	5	view →
GBM	DFS	Median	All	0.823	0.679	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

DEF8–CCRCC (OS)

Open the CCRCC breakdown →