DEF8

Across TCGA patient cohorts, DEF8 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,977 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DEF8-associated proteins across cancer lineages are MEAK7, CBFB, and RPL35A. Each is linked with DEF8 in more than 3 cancer types. Because this analysis shows association rather than direction, both DEF8-to-partner and partner-to-DEF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEF8 versus MEAK7 in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF8→partner) and Y-score (partner→DEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEAK7 →	+0.407	+0.363	<.001	<.001	3	4
OV	CBFB →	+0.352	+0.551	.004	.001	3	4
GBM	RPL35A →	-0.287	-0.306	<.001	<.001	3	3
GBM	RPL4 →	-0.290	-0.238	.003	.008	3	3
COAD	RPL8 →	-0.276	-0.298	.008	.006	3	3
OV	HSDL1 →	+0.453	+0.558	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,977 associations by consensus.

DEF8 vs MEAK7 — LSCC

Explore this scatter interactively →